Dan plays as Fondue Zubag, a half-orc ranger, and he has a regular cast that plays with him, in front of a live audience, with a guest comedian. The episodes are then animated and cut between the animation of the game and the players around a table.
Paul F. Tompkins was the guest in episode 1 (who played as Teflonto, Earthscar's village champion and captain of the town's militia. Also a friend, mentor, and role model to Fondue). Looking at the episode list, here are some of the guest players: Aubrey Plaza, Thomas Middleditch, Kumail Nanjiani, Patton Oswalt and Nathan Fillion.
If you're a fan of Dungeons and Dragons, or just comedy, I 100% recommend checking this out! (It does require setting up a free account to watch)