This one gives a lot of plot information that we haven't gotten before. It looks like everyone's speculations have been proven right, and a large portion of the main plot will revolve around The Institute (MIT, most likely) and their synthetic people.
Fallout 3 had a questline that introduced us to the Institute and we met a synth, and depending on our characters we helped or harmed their mission. A year or two later, people spotted some Bethesda employees taking pictures around Boston and assumed that Fallout 4 would heavily involve The Institute, and boy were they right!
It's a common sci-fi trope to have a new class of people who are mistrusted and misunderstood be a metaphor for racism, homophobia, or other prejudices, but it's common because it's powerful.
I can't wait to get my hands on this!