First off I think it warrants mentioning I don't like games that are very hard. Since this game is a rogue-like expect that you will die. A lot. Basically you need to crawl X amount of dungeons to go head-to-head with Mom, beat her and win the game.
After playing a few days in a row I never got further than floor 4.
I like that the game has religious overtones and doesn't apologize for its take on the material. The playable characters of the game are Issac, Cain, Eve, Judas and a few others that don't come to mind. Issac is the only character unlocked by default, you can unlock the rest by doing things in the game. I like that the playable characters are people that don't get a ton of love in the Bible, the misfits as it were. It makes sense in the tone of the game, but I don't want to spoil the entire tone of the game.
If you really love rogue-likes then you need to play this game. If you love Zelda and need to see when people pay homage, then check this game out. If you like Bible material flipped around in non-traditional ways then check this out. All in all, its a fun game and worth looking into I just didn't stick with me as I don't like the punishing nature of rogue-likes.